Semi-related, but I was just thinking today I wonder what sort of performance improvements, if any, one could see by having one of the frontier models build a operating system from scratch that targets the subset of imports WINE uses as the standard library? Basically, build whatever syscalls (or shims) WINE and the open source vulkan drivers need and nothing more.
Probably outside the scope of what an individual could pull off on thier own in a reasonable time, but I could totally see for example Valve considering that approach for a later iteration of SteamOS.