alt Hacker NewsI have been going back and forth between Luxi Mono (serif monospace fonts are rare but look great on high-resolution monitors) and Hack (like Helvetica, it has virtually no personality and thus fits well everywhere). Everything else I've seen has looked... weird or off somehow. But this is one of the first alternatives I'm entertaining the idea of trying.
My main concern is that the tall glyphs for less than < and greater than > will disambiguate badly with actual Unicode left 〈 and right angle brackets 〉.
Edit: I also realised just now the ASCII hyphen-minus - is quite long with this typeface, which makes it ambiguous with the longer dashes. (It looks freakin' great in pure ASCII environments, though!)
The hyphen is as wide as the em dash (it's one pixel higher than the em-dash—the only visible difference to my eyes). And the $ symbol doesn't have a line that goes through all the way through. It doesn't work for me for daily use, but looks quite clean and nice overall.