It orchestrated available open source tools to de novo generate and assess the designs. It is still really impressive that it has enough theory to use the tools correctly, but it isn't generating the residues from scratch within the model itself.

I got Opus5 to write me a enzyme design pipeline on AWS last month using available tools and databases. It works fine. It's not as handsoff as you might think when you start looking at more complex proteins with multiple binding pockets and sequential catalytic process within multimeric structures. The bottleneck is still actually testing the candidates out in the lab.