alt Hacker NewsI think the important bit is that, from my understanding, mouse models of alzheimer's dont translate as reliably to humans as it does for other diseases
I think the important bit is that, from my understanding, mouse models of alzheimer's dont translate as reliably to humans as it does for other diseases
This is correct, mice don’t naturally experience alzheimer’s or other dementias during their lifespans and the structure of their amyloid beta protein is different as well. To continue using them as model organisms, we have to induce the disease in them by either introducing human genes that are linked with alzheimer’s, or chemically inducing a disease state that we believe to be similar. Mice are much better models organisms for studying metabolism or cancer, by comparison.