There is a wide range.
I have two people in my extended family with Down Syndrome. It's not the "bro" version that Shane Gillis talks about or the TV-friendly version like on Life Goes On.
They are both severely impaired, nonverbal, and demand constant attention. I only see them a few times per year and even within those isolated windows, I find it exhausting.
Some of the stuff would sound cute if done once or twice, but when it's every 2-3 minutes all day long... it's hard.