For Oryx and Crake and sequels, it's hard to argue that "a novel with no robots or spaceships ... but a whole lot of genetic engineering" isn't actually SF.

It doesn't pass the test that e.g. a novel set on the actually existing International Space Station does. It does contain a core fictional scientific "what-if" extrapolation.

I respect the author's opinion here and I hold a different opinion, for that reason.