Lots of scary stuff has been possible for ages. Much of it is so easy that wouldn't be publishable because of lack of novelty.

I see LLMs as being essentially irrelevant for whether someone can do this. It's lab skills, planning skills, biological experiment debugging skills.

"Why did my plasmid not start getting expressed, how did I screw up?" "How do I make this huge protein" aren't LLM questions, they're university level biology questions, and "why is my protein growth tank not making the thing I want, and what is the grey stuff, do I need to put clean it again" is an experience question.

Putting checks on DNA synthesis puts making the horrible stuff out of the range of what high schoolers can do though.