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Found: A protein that drives ageing without unleashing inflammation

98 points • by gumby • yesterday at 7:25 PM • 18 comments • view on HN

Comments

neom • yesterday at 8:39 PM

Paper: https://www.cell.com/immunity/fulltext/S1074-7613(26)00440-1

Granzyme K is the protein.

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ethanj8011 • yesterday at 10:49 PM

From the abstract of the paper, significantly more nuance.

> Despite persistent immune aging phenotypes, GzmK deficiency markedly attenuated organ aging, effectively uncoupling immune and tissue aging... These findings identify GzmK as a tissue-specific driver of organismal aging but not immune aging or systemic inflammaging.

RobotToaster • yesterday at 9:23 PM

Paywall

StilesCrisis • yesterday at 9:18 PM

Thank God! Finally, mice that don't age!

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agnosticmantis • yesterday at 8:14 PM

In mice.

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