alt Hacker NewsOne thing I have noticed on Mounjaro is a (at least subjectively) significant decrease in impulse spending / buying random crap off Amazon. I have ADHD and that has been a real problem for quite a while - even with ADHD medication (Elvanse/Vyvanse in my case).
The part of Mounjaro that regulates the craving side of the weight loss equation (like reducing 'food noise' and the desire for sugary and fatty foods) seems to also affect other behaviors due to Mounjaro's effect on the brain's reward circuitry. I believe there are also early preliminary studies that indicate it can help with addictions like alcoholism.
Those drugs really are quite something. Shame they're so damn expensive. Insurance here in Germany is unfortunately legally prohibited from covering GLP-1 class drugs for weight loss unless you have a diabetes diagnosis.
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Are the drugs actually expensive, or just expensive for now because they can be?
Modern society basically decided that adding flouride to drinking water and iodine to table salt for everyone was better than dealing with tooth decay and gout.
I understand that peptide synthesis and cold-chain logistics are not as trivial as these elements, but this paper [1] estimates that GLP1 manufacturing costs can be under a dollar per person per month, orders of magnitude less than current market rates!
Perhaps our future society will normalize taking a daily GLP-1 agonist with their other multivitamins at breakfast.
[1]: https://jamanetwork.com/journals/jamanetworkopen/fullarticle...
That’s really neat.
I’m ashamed that I have this wish that I were overweight and had an excuse to try a GLP1 just to see how it would affect my impulse control with non-food habits.
I guess there’s not much stopping me from buying some unregulated drugs from the internet and self-experimenting, but I haven’t heard experiences from people deliberately using them for anything but weight.
On Wegovy(semaglutide) I haven't noticed any change in my binges or impulsiveness. Slightly worse(not dramatic) depressive episodes but that's about it.
That would go in line with what I've read of it helping people with mild addictions.
I've been on Mounjaro and find it pretty inexpensive, but I'm using a high-dose pen for a low-dose injection. One 15mg pen is going to last me around 6 months at my current rate, so around 15 euros per week.