Sorry can you explain more the connection between PyPy and CFFI (which generates compiled extension modules to wrap an existing C library)? I have never used PyPy, but I use CFFI all the time (to wrap C libraries unrelated to Python so that I can use them from Python)
CFFI is fast on PyPy. The JIT still cannot peer into the compiled C/C++ code, but it can generate efficient interface code since there is a dedicated _cffi_backend module built into PyPy. Originally that was the motivation for the PyPy developers to create CFFI.