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staticassertionyesterday at 12:59 PM1 replyview on HN

That's not the exact quote lol you cut out the exact part I was referring to.

> because unless a really substantial amount of engineering has gone into it, any given peptide is going get the same treatment from your digestive system as a chicken breast does, i.e. a complete teardown

> Every single YouTube video and blog post I have read about peptites is exclusively about injectable supplements.

Collagen peptides, ghk-cu, and many other peptide supplements are often taken orally.


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malfistyesterday at 3:50 PM

> Collagen peptides, ghk-cu, and many other peptide supplements are often taken orally.

And with very rare exceptions, it's as useful as watching someone workout when you want to gain muscle. Every meat we eat is awash in peptides, and to keep our body from getting hijacked by the signaling for, say a chicken, our body has to break down almost all peptides ingested orally.

There are a few exceptions, notably there's one that is produced by our own bile acid, that can be taken orally, and then SNAC, which was developed by Novo Nordisk over thirty years and has extremely limited capabilities and is fully patented and cannot be made by your fly by night distributers. SNAC achieves a whopping 1% bioavailability of the peptide, and it's ability to work depends on the size of the peptide, specifically the only commercially available use for this is Rybelsus.

Oral peptides are snake oil for the most part.

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