alt Hacker NewsWhy would biological systems be a counterargument? Smelting metals and sustaining life both require an enormous amount of water and about ~1ATM of atmosphere, as far as we know, and there's no plausible known mechanism for sidestepping this requirement. So "magical synthetic biology that can self-replicate in space" is actually a worse solution to the problem than "magical metallurgy that can be done in space" since humans at least have smelted metals, but we've never built synthetic forms of life. (Not counting CRISPR)
You're making assumptions that the parent isn't necessarily making. Imagine sending humans to other earthlike planets on hypothetical generation ships. Those humans could throw away their technology and rebuild from zero over thousands of years to send more spaceships of humans to yet further planets. Presto, an example of self-replicating biological von Neumann systems.