Yes! I remember finding out which integer was the money in my Sim City save. And I remember when I figured out the build order list for Star Trek: Armada 2 and fixed the Borg AI to be so formidable that we'd have to play the First Contact sound track at full blast to even have a chance of winning against 3 Borg players.
By later times it seems this was tougher, I remember trying it with Ultima IX and utterly failing to locate a single relevant memory location after a solid week.